Publications

2025
    • Cho, H., Ju, H., Ahn, Y., Jang, J., Cho, J., Park, E., Kang, S-M., Jaemin Lee, Seo, D., Baek M-C., Yea, K., 2025. Engineered extracellular vesicles with surface FGF21 and enclosed miR-223 for treating metabolic dysfunction-associated steatohepatitis. Biomaterials 2025, 321: in press. View at Publisher
2024
    • Gao, Y., Ryu, H., Lee, H., Kim, Y-J., Lee, J-H.*, Lee, Jaemin*. ER Stress and Unfolded Protein Response (UPR) Signaling Modulate GLP-1 Receptor Signaling in the Pancreatic Islets. Molecules and Cells 2024, 47(1):100004. *co-corresponding authors. View at Publisher
    • Jung, S-R.*, Lee, J-H., Ryu, H., Gao, Y., Lee, Jaemin*. Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis. Korean Journal of Physiology & Pharmacology 2024, 28(1):31-38. *co-corresponding authors. View at Publisher
    • Lee, Jaemin. Exploring renal pyruvate metabolism as a therapeutic avenue for diabetic kidney injury. Diabetes & Metabolism Journal 2024, 48(3):385-386. (Editorial) View at Publisher
2023
    • Lee, J-H., Ryu, H., Lee, H., Yu, H.R., Gao, Y., Lee, K-M., Kim, Y-J., Lee, Jaemin. Endoplasmic Reticulum Stress in Pancreatic β Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression. American Journal of Physiology-Endocrinology and Metabolism 2023, 325:E448-E465. View at Publisher.
    • Jung,S.-R.*, Lee,J.-H., Jaemin Lee*. Lithium and exercise ameliorate insulin-deficient hyperglycemia by independently attenuating pancreatic α-cell mass and hepatic gluconeogenesis. Research Square preprint 2023. *co-corresponding authors. View at Publisher Published in the Korean Journal of Physiology and Pharmacology (2024).
2022
    • Kang, S., Choi, L.S., Im, S., Kim, J.H., Lee, K.W., Kim, D.H., Park, J.H., Park, M.-H., Lee, Jaemin, Park, S.K., Kim, K.P., Lee, H.M., Jeon, H.J., Park, H.S., Yoo, S.-K., Pak, Y.K. Vutiglabridin improves neurodegeneration in MPTP-induced Parkinson’s disease mice by targeting mitochondrial paraoxonase-2. bioRxiv preprint 2022. View at Publisher
    • Kim, S., Kim, D.K., Jeong, S.H., Lee, Jaemin. The common cellular events in the neurodegenerative diseases and the associated role of endoplasmic reticulum stress. International Journal of Molecular Sciences 2022, 23:5894. View at Publisher
    • Lee, J-H., Lee, Jaemin. Endoplasmic reticulum (ER) stress and its role in pancreatic β-cell dysfunction and senescence in type 2 diabetes. International Journal of Molecular Sciences 2022, 23:4843. View at Publisher
    • Park, B.G., Kim, G.M., Lee, H-J., Ryu, J.H., Kim, D-H., Seong, J-Y., Kim, S., Park, Z-Y., Kim, Y-J., Lee, Jaemin*, Kim, J.I.*. Anti-obesity therapeutics with complementary dual-agonist activities at glucagon and glucagon-like peptide 1 receptors. Diabetes, Obesity and Metabolism 2022, 24(1):50-60. *co-corresponding authors. View at Publisher
    • Kim, D.K., Lee, Jaemin. Physiological Function of Insulin-like Peptides in Insects. Korean Journal of Applied Entomology 2022, 61(1):85-90. (In Korean). [김두경, 이재민. 곤충 insulin-like peptide의 생리 조절 작용. 한국응용곤충학회지 2022, 61(1):85-90.] View at Publisher
2019
    • Gao, Y., Kim, S., Lee, Y-I*, Lee, Jaemin*. Cellular stress-modulating drugs can potentially be identified by in silico screening with connectivity map (CMap). International Journal of Molecular Sciences 2019, 20:5601. *co-corresponding authors. View at Publisher
    • Cho, B., Kim, T., Huh, Y.-J., Lee, Jaemin*, Lee, Y.-I*. Amelioration of Mitochondrial Quality Control and Proteostasis by Natural Compounds in Parkinson’s Disease Models. International Journal of Molecular Sciences 2019, 20:5208. *co-corresponding authors. View at Publisher
    • Feng, X., Guan, D., Auen, T., Choi, J.W., Salazar Hernandez, M.A., Lee, Jaemin, Chun, H., Faruk, F., Kaplun, E., Herbert, Z., Copps, K.D., Ozcan, U. IL1R1 is required for celastrol’s leptin sensitization and anti-obesity effects. Nature Medicine 2019, 25(4): 575-582. View at Publisher
2018
    • Lee, Jaemin*, Salazar Hernandez, M.A., Auen, T., Mucka, P., Lee, J., Ozcan, U*. PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism. Molecular Metabolism 2018, 7:119-131. *co-corresponding authors. View at Publisher
2017
    • Sharabi, K., Lin, H., Tavares, C.D.J., Dominy, J.E., Camporez, J.P., Perry, R.J., Schilling, R., Rines, A.K., Lee, Jaemin, Hickey, M., Bennion, M., Palmer, M., Nag, P.P., Bittker, J.A., Perez, J., Jedrychowski, M.P., Ozcan, U., Gygi, S.P., Kamenecka, T.M., Shulman, G.I., Schreiber, S.L., Griffin, P.R., Puigserver, P. Selective chemical inhibition of PGC-1α gluconeogenic activity ameliorates type 2 diabetes. Cell 2017, 169(1):148-160. View at Publisher
2016
    • Liu, J., Ibi, D., Taniguchi, K. Lee, Jaemin, Herrema, H., Akosman, B., Mucka, P., Salazar Hernandez, M.A., Uyar, M.F., Park, S.W., Karin, M., Ozcan, U. Inflammation improves glucose homeostasis through IKKβ-XBP1s Interaction. Cell 2016, 167(3):1052-1066. View at Publisher
    • Lee, Jaemin*, Liu, J.*, Feng, X.*, Salazar Hernandez, M.A., Mucka, P., Ibi, D., Choi, J-W., Ozcan, U. Withaferin A is a Leptin Sensitizer with Strong Anti-diabetic Properties in Mice. Nature Medicine 2016, 22(9): 1023-1032. *co-first authors. View at Publisher
2015
    • Liu, J.*, Lee, Jaemin*, Salazar Hernandez, M.A., Mazitschek, R. Ozcan, U. Treatment of obesity with celastrol. Cell 2015, 161(5): 999-1011. * co-first authors. View at Publisher
Past Publications (2014 and before)
    • Lee, Jaemin, Ozcan, U. Unfolded protein response signaling and metabolic diseases. Journal of Biological Chemistry 2014, 289(3): 1203-1211. View at Publisher
    • Herrema, H., Lee, Jaemin, Zhou, Y., Copps, KD., White, MF., Ozcan, U. IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochemical and Biophysical Research Communications 2014, 443(2): 689-693. View at Publisher
    • Wright, J., Wang, X., Haataja, L., Kellogg, AP., Lee, Jaemin, Liu, M., Arvan, P. Dominant protein interactions that influence the pathogenesis of conformational diseases. Journal of Clinical Investigation 2013, 123(7): 3124-3134. View at Publisher
    • Lee, Jaemin*, Sun, C.*, Zhou, Y., Lee, J., Gokalp, D., Herrema, H., Park, SW., Davis, RJ., Ozcan, U. p38 MAPK-mediated Regulation of Xbp1s is Crucial for Glucose Homeostasis. Nature Medicine 2011, 17(10): 1251-1260. *co-first authors. View at Publisher
    • Lee, Jaemin, Di, Jeso. B., Arvan, P. Maturation of Thyroglobulin Region-I. Journal of Biological Chemistry 2011, 286(38): 33045-33052.
    • Lee, Jaemin, Arvan, P. Repeat Motif-containing Regions within Thyroglobulin. Journal of Biological Chemistry 2011, 286(30): 26327-26333.
    • Zhou, Y., Lee, J., Reno, CM., Sun, C., Park, SW., Chung, J., Lee Jaemin, Fisher, SJ., White, MF., Biddinger, SB., Ozcan, U. Regulation of Glucose Homeostasis through a XBP-1-FoxO1 Interaction. Nature Medicine 2011, 17(3): 356-365.
    • Park, SW., Zhou, Y., Lee, Jaemin, Lee, J., Ozcan, U. Sarco(endo)plasmic Reticulum Ca2+-ATPase 2b is a Major Regulator of Endoplasmic Reticulum Stress and Glucose Homeostasis in Obesity. Proceedings of the National Academy of Sciences 2010, 107(45): 19320-19325.
    • Peteiro, D.*, Lee, Jaemin*, Rodriguez-Fontan, J., Castro-Piedras, I., Cameselle-Teijerio, J., Beiras, A., Alvarez, CV., Hardy, DM., Targovnik, HM., Arvan, P., Lado-Abeal, J. New Insights into Thyroglobulin Pathophysiology Revealed by the Study of a Family with Congenital Goiter. Journal of Clinical Endocrinology and Metabolism 2010, 95(7): 3522-3526. *Co-first authors
    • Wang, X., Lee, Jaemin, Di, Jeso. B., Treglia, AS., Comoletti, D., Dubi, N., Taylor, P., Arvan, P. Cis and Trans Actions of the Cholinesterase-like Domain within the Thyroglobulin Dimer. Journal of Biological Chemistry 2010, 285(23): 17564-17573.
    • Choi, K., Lee, Jaemin, Park, J., Cho, J., Song, J., Kim, D., Boo, K. Sex Pheromone Composition of the Cotton Caterpillar, Palpita indica (Lepidoptera: Pyralidae), in Korea. Journal of Asia-Pacific Entomology 2009, 12(4): 269-275.
    • Lee, Jaemin, Wang, X., Di, Jeso. B., Arvan, P. The Cholinesterase-like Domain of Thyroglobulin, Essential in Thyroglobulin Trafficking for Thyroid Hormone Synthesis, is Required for Protein Dimerization. Journal of Biological Chemistry 2009, 284(19): 12752-12761.
    • Lee, Jaemin, Di, Jeso. B., Arvan, P. The Cholinesterase-like Domain of Thyroglobulin Functions as an Intramolecular Chaperone. Journal of Clinical Investigation 2008, 118(8): 2950-2958.
    • Kim, PS.*, Lee, Jaemin*, Jongsamak, P.*, Menon, S., Li, B., Hossain, SA., Bae, JH., Panijpan, B., Arvan, P. Defective Protein Folding and Intracellular Retention of Thyroglobulin-R19K Mutant as a Cause of Human Congenital Goiter. Molecular Endocrinology 2008, 22(2): 477-484. *Co-first authors
    • Menon, S., Lee, Jaemin, Abplanalp, WA., Yoo, SE., Agui, T., Furudate, S., Kim, PS., Arvan, P. Oxidoreductase Interactions Include a Role for ERp72 Engagement with Mutant Thyroglobulin from the Rdw/rdw Rat Dwarf. Journal of Biological Chemistry 2007, 282(9): 6183-6191.
    • Choi, M, Lee, Jaemin, Han, KS., Boo, KS. Identification of a New Member of PBAN Family and Immunoreactivity in the Central Nervous System from Adoxophyes sp. (Lepidoptera: Tortricidae). Insect Biochemistry and Molecular Biology 2004, 34: 927-935.